BGI provides LC-MS/MS peptide mapping services to support biopharmaceutical and biotechnology applications. Our Peptide Mapping services are designed to characterize and monitor the molecular details of a therapeutic protein drug at each position in the amino acid sequence1,2.
Project Workflow
Sequence Verification
We provide amino acid sequence verification services and PTM mapping for purified proteins. Our service is useful for accurately validating expression of recombinant proteins or identifying process related PTMs on biologic drugs.
Individual samples
Gentle sample preparation
LC-UV-MS/MS DDA Analysis
Peptide map data analysis
Molecular Assessment
We can help you characterize amino acid sequence liability. We provide a Molecular Assessment service to monitor specific amino acid modifications in response to a forced degradation treatment customized to meet your project needs. Our service is optimized for high dynamic range peptide sequence coverage.
Sample batch
Individual samples
Forced sample degradation series
Gentle sample preparation
LC-UV-MS/MS DDA Analysis
Peptide map data analysis
Molecular Assessment Profile
References
[1]. Lauber MA, Koza SM, McCall SA, Alden BA, Iraneta PC, Fountain KJ. High-resolution peptide mapping separations with MS-friendly mobile phases and charge-surface-modified C18. Anal Chem. 2013 Jul 16;85(14):6936-44. doi: 10.1021/ac401481z.
[2]. Mouchahoir T, Schiel JE. Development of an LC-MS/MS peptide mapping protocol for the NISTmAb. Anal Bioanal Chem. 2018 Mar;410(8):2111-2126. doi: 10.1007/s00216-018-0848-6.
